INTRODUCTION Primary myelofibrosis (PMF) is an acquired clonal disorder of hematopoietic stem cells with abnormal proliferation of myeloid cells. PMF is a Bcr-Abl (Breakpoint cluster region protein-Abelson tyrosine-protein kinase, Eng.) negative myeloproliferative neoplasm (MPN) [1,2]. It is...

INTRODUCTION Central nervous system involvement in multiple myeloma (CNS-MM) is a very rare entity with an incidence lower than 1% of all extramedullary multiple myeloma [1]. Over the past decade, an increase in the incidence of this entity was observed, primarily due to the improvement of...

INTRODUCTION Hodgkin’s lymphoma is a chronic malignant lymphoproliferative disease with a bimodal distribution of occurrence in the third decade of life as well as in the sixth decade [1]. Considering that the first peak also includes women in the reproductive period, the literature incidence of...

INTRODUCTION Ferroptosis, first mentioned in a study by Dixon et al. in 2012, is a non-apoptotic, non-necrotic, and non-autophagic form of cell death [1]. In 2003, Dolma et al. discovered that erastin can cause a new type of cell death, upon which Yagoda and Yang reported that iron chelators...

INTRODUCTION Light chain deposition disease, according to the 5th revision of the classification of hematopoietic and lymphoid tissue diseases of the World Health Organization, belongs, as the most common entity, to the group of monoclonal immunoglobulin deposition diseases, which also includes...

INTRODUCTION Disruption in the immune system regulation and abnormal production of autoantibodies can cause many autoimmune diseases. Autoantibodies directed against specific antigens are usually associated with a typical clinical presentation such as the rheumatoid factor in rheumatoid...

INTRODUCTION Primary myelofibrosis (PMF) is a clonal disorder of hematopoietic stem cells, marked by specific genetic mutations and pathophysiological changes that disrupt the normal maturation of megakaryocyte and granulocyte lineage cells in the bone marrow [1,2]. All Philadelphia-negative...

INTRODUCTION Vitamin K antagonists (VKAs) have been a cornerstone in preventing and treating venous thromboembolism (VTE) for over half a century. However, their use also has numerous difficulties, such as a delayed onset/ offset of action, individual dosage variability, numerous drug and...

INTRODUCTION Medications are a frequent cause of thrombocytopenia, particularly among hospitalized patients. Thrombocytopenia has been associated with the use of over 300 different medications, a list of which is available at “Platelets on the web” (https://www.ouhsc.edu/ platelets/ditp.html)...

INTRODUCTION Anemia remains a major global health problem, although a significant downward trend has been observed in recent years, thanks to preventive measures. Based on the analysis conducted in 2019, in 204 countries worldwide, it has been estimated that 1.8 billion people have anemia, with...

INTRODUCTION Classical Hodgkin lymphoma (cHL) accounts for approximately 95% of all HL cases. The remaining 5% are patients with nodular lymphocyte-predominant Hodgkin lymphoma, a histological subtype with significantly different treatment and prognosis. Within the most recent classification of...

INTRODUCTION Younger patients with myeloproliferative neoplasms (MPN) represent a special subpopulation of patients whose number is gradually increasing [1]. The median age at diagnosis for classic BCR-ABL1-negative MPNs, which include polycythemia vera (PV), essential thrombocythemia (ET), and...

INTRODUCTION Multiple myeloma (MM) is a malignant disease belonging to the group of monoclonal gammopathies originating in the bone marrow. It is characterized by the uncontrolled proliferation of tumorous B-lymphocytes – plasma cells, which produce pathologically altered immunoglobulins...

INTRODUCTION Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors represent an optimal therapeutic option in the first or second line of treatment for metastatic hormone receptor-positive (HR+), human epidermal growth factor receptor 2 (HER2)-negative breast cancer. These drugs are administered...

INTRODUCTION Chemotherapy-induced neutropenia is one of the most common side effects of treatment and is often complicated by febrile neutropenia (FN). Neutropenia occurs in almost a fifth of hematological patients, except for patients who undergo hematopoietic stem cell transplantation, among...

INTRODUCTION Acute myeloid leukemia (AML) is a heterogeneous malignant disease of the hematopoietic system characterized by clonal proliferation of undifferentiated myeloid precursors, i.e. blasts [1]. As a result of the accumulation of immature cells, normal hematopoietic cells are suppressed...

INTRODUCTION Acute myeloblastic leukemia (AML) is an umbrella term for a heterogeneous group of clonal neoplastic diseases of hematopoietic cells. The use of intensive chemotherapy, with or without the use of small molecule inhibitors or immunotherapy, leads to a high percentage of...

Nothing is final as long as we continue to search... Meša Selimović Dear colleagues and friends, Doctors and all healthcare workers have always been...

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